Radiological Imaging Advances to Improve Characterization of COVID-19 Disease Burden, Progression and Recovery

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This project relies on “Establishing an affordable, secured research cloud solution for large-scale computing against COVID-19 healthcare data” core project. COVID-19 has been found to injure important organ systems such as the lung and brain. Survivors of COVID-19 may suffer long term disability arising from the acute phase of the disease, and new approaches are needed to image and quantify the disease burden, progression, and recovery in these patients. While conventional MRI and CT have been helpful at revealing aspects of injury, novel techniques offer the prospect of improved precision. For example, dual-energy CT offers the possibility of quantitatively characterizing lung parenchyma, fluid accumulation, and blood in a manner not possible with conventional CT. Advanced MRI techniques provide an improved characterization of cytokine storm induced encephalopathy arising from viral infection-induced blood-brain barrier breakdown. Advanced imaging reconstruction and analysis require scalable computing resources.

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